Precisely Molded Nanoparticle Displaying DENV-E Proteins Induces Robust Serotype-Specific Neutralizing Antibody Responses.
Dengue virus (DENV) is the causative agent of dengue fever tru spec softshell jacket and dengue hemorrhagic fever.The virus is endemic in over 120 countries, causing over 350 million infections per year.Dengue vaccine development is challenging because of the need to induce simultaneous protection against four antigenically distinct DENV serotypes